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Increased Risk of Toxicity with Ibuprofen in Patients with Renal Impairment: Advise patients with mild to moderate renal impairment of the risks associated with concomitant ibuprofen use and instruct them to avoid use of all ibuprofen containing products for 2 days before, the day of, and 2 days following administration of Pemetrexed for Injection, USP [see Dosage and Administration (2.5), Warnings and Precautions (5.6), and Drug Interactions (7)]

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Antioxidant benefits may occur earlier

Therefore, targeting NQO1 may be a sensible strategy to promote cell death and maximize the curative effect of radiotherapy, which is frequently used to treat rectal cancer