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Description

Melanoma cells use Thy-1 (CD90) on endothelial cells for metastasis formation

Nucleic Acids Res 39 , e142 (2011)

Via pattern-recognition receptors, these cells sense pathogen- and damage-associated molecular patterns (PAMPs and DAMPs), triggering the production of proinflammatory cytokines (e.g., TNF-, IL-1, IL-6) and chemokines that drive the inflammatory cascade ( Within the adaptive immune compartment, imbalances in T and B lymphocytes sustain chronic inflammation and ongoing tissue injury