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Nevertheless, two placebo-controlled crossover studies demonstrated that 2 months of folate supplementation improves endothelial function in hyperhomocysteinemic subjects by decreasing homocysteine levels (Bellamy et al, 1999

[Google Scholar] 4.Burkill I.H

(Green R, et al., Nature Reviews Disease Primers, 2017 PubMed: 28660890 ) Because B12 is water-soluble, excess amounts that the body cannot use are excreted in urine rather than stored

Factors That Affect Your Metabolism Several factors affect how quickly you process substances, including: Body weight Biological sex Age Overall health Genetics People with larger body mass generally process alcohol slightly faster, while certain medications can slow the process