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These cells remain sequestered in the dermis for months to years, where the Tyndall effect translates deep-seated pigment into a clinically characteristic gray-blue hue [156]

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Other drugs that may be used to treat migraine include ergot alkaloids , which cause blood vessel constriction, opioids , and, less commonly, corticosteroids (MD Consult 2011)

The April 2024 landmark paper proposing BPC-157 as a cytoprotection mediator with neurotransmitter-like activity provides an elegant theoretical framework, but elegance is not evidence