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Multiple evidence-driven hypotheses have sought to determine the cell of origin that initiates CNs through Knudsons Second Hit in the remaining wild-type NF1 gene

PMID: 2237408

Based on converging evolutionary and mechanistic evidenceencompassing mitochondrial centrality in hypoxic response, natural selection of the Tibetan-enriched mitochondrial DNA haplogroup M9a, and bidirectional ROS-HIF regulatory crosstalkwe propose a mechanistic hypothesis that mitochondrial retrograde signaling orchestrates nuclear genomic reprogramming through modulation of HIF-responsive elements to establish hypoxia-tolerant phenotypes

Prostaglandin E1 Improves Cerebral Microcirculation Through Activation of Endothelial NOS and GRPCH1