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These events correlated with increased lipid peroxidation byproducts, ER stress, decreased protective ER chaperones, and greater cell death and liver injury ( Genetics of alcoholic liver disease Gender differences in the progression of ALD with females being more susceptible than males in the background of similar levels of consumption of alcohol, interethnic differences, and higher concordance for cirrhosis in monozygotic twins as compared to dizygotic twins, all point to the role of genetic modifiers for the phenotype

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& Kedinger, M