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13 Inclusion criteria: The sample included adults (age 18 years) with 13 : 1 inpatient primary MS diagnosis or 2 outpatient MS diagnoses in any position 30 days apart in the 12 months prior to (preindex period) or 6 months following the index date First claims were recorded on or after the index date of August 20, 2020, and continuous enrollment in a commercial insurance plan 12 months before and 24 months after the index date The index date was defined as the date of the first KESIMPTA or Ocrevus claim, which was by design after the KESIMPTA US Food and Drug Administration approval on August 20, 2020 Optum Clinformatics Data Mart Database is a longitudinal database of medical and pharmacy administrative claims for patients enrolled in commercial insurance and Medicare Advantage plans in the United States

Use fresh diluent and maintain strict sterility throughout reconstitution and injection

These observations suggest that the actions of DSIP on substance P, beta-endorphin, and corticosterone are indicative of a wider array of biochemical modifications, proposing that DSIP may trigger a cascade of molecular events that may facilitate its stress-modulatory functions

The dosing of Epitalon was based on a 15-year study done in Russia