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It is secreted by the adipose tissue, and its levels are increased in diet-induced and genetic forms of obesity [200]

It has been shown to modulate nitric oxide and growth factor activity, which enhances blood flow and nutrient delivery to damaged tissue

Large population studies now show that women who experience severe or early-onset hot flashes are more likely to exhibit changes in arterial health, including endothelial dysfunction and subclinical atherosclerosis