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Combinations of gonadotropins have been found to be equally effective for treating hypogonadotropic hypogonadism, and are less expensive and less invasive than pulsatile GnRH therapy

The review article details analytical challenges such as heterophilic antibodies, pituitary HCG in peri and postmenopausal women, and variant forms that may cause false positive or negative results, guiding assay design and interpretation

NICE-approved weight management pathways, including licensed pharmacotherapy and specialist referral, are the appropriate starting point