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In addition, the role of glucose metabolism impairment was observed in a meta-analysis encompassing more than 1,700,000 patients, finding diabetic patients to have a 38% higher risk of development of PD (Yue et al., 2016), while in another meta-analysis on 86,000 PD patients, prediabetic patients were found to have a 4% higher risk of development of PD compared to individuals with no fasting glucose impairment ( 2.4 Mitochondrial dysfunction Mitochondria are crucial for insulin secretion from pancreatic cells, and their dysfunction contributes to impaired insulin secretion in T2DM

10.1105/tpc.12.5.707 Plant Cell 69 SanjanaN

Besides, KEGG pathway analysis showed that 57 significantly altered metabolites were mainly enriched in amino acid metabolic pathways, such as glutathione metabolism, glycine and threonine metabolism, and tryptophan metabolism

Nicotinamide reduces the expression of human leukocyte antigen-DR and ICAM-1 stimulated by cytokines in orbital fibroblasts during the active phase of TAO (110)