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In particular, four compounds, i.e., 5154, were purchased from Enamine (Supplementary Table 2), whereas 25 analogues, i.e., 5579, were synthesized, along with hit 3, in an optimized one-step procedure, as illustrated in Supplementary Scheme 1

Legendplex The Legendplex Mouse Th Cytokine Panel V03 (BioLegend, San Diego) was used according to the manufacturers protocol

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