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In addition, resveratrol and curcumin have also been shown to stimulate GLP-1 secretion and/or enhance incretin receptor responsiveness, thereby improving insulin sensitivity and metabolic homeostasis in diabetes models (Dao et al., 2011

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These factors collectively contribute to a ferroptosis cascade characterized by iron metabolism imbalance, oxidative stress, and lipid peroxidation, Further intensifying neuronal and oligodendrocyte mortality while eliciting inflammatory responses via the release of Damage-Associated Molecular Patterns (DAMPs), forming a vicious cycle that ultimately leads to irreversible damage to spinal cord tissue

GSH, an intracellular tripeptide, is involved in several critical functions, including cellular proliferation