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Numerous ex vivo organ culture studies and large animal models, including rats, rabbits, dogs, and pigs, have demonstrated that minimally invasive injection or percutaneous implantation of hydrogels loaded with transforming growth factor-3, anti-apoptotic miRNA, or autologous mesenchymal stem cells can maintain IVD height, restore its viscoelastic storage modulus, and delay or even partially reverse tissue degeneration (Yang S

& Evans, P

When NNMT becomes overactive, particularly in adipose tissue, it depletes cellular NAD+ reserves while promoting fat storage and metabolic inefficiency

We found concordant differential expression of these emphysema severity-associated genes in four cross-sectional studies of COPD