melanotic nodule Congenital melanocytic nevus Images of Amelanotic Melanoma —

Multiple causes of hyperpigmented lesions of the oral mucosa are known, with oral and labial melanotic macules as the most common melanotic lesions.1,2 Trauma, radiation, and medications may result in an increased production of melanin seen in melanotic macules, but the pathophysiological mechanism of this disorder is still unknown.1,2 Histologically, melanotic macula of the oral and labial mucosa is characterized by increased melanin in the basal cell layer and lamina propria

Ongoing monitoring enables timely dose adjustments and supports safe continuation of therapy

Melanocortin Receptor Pharmacology As a non-selective melanocortin agonist, MT-II engages multiple receptor subtypes

[PUBMED Abstract] Hayes AJ, Maynard L, Coombes G, et al.: Wide versus narrow excision margins for high-risk, primary cutaneous melanomas: long-term follow-up of survival in a randomised trial