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We list it as our high-potency pick for two specific scenarios: anyone with documented deficiency working to replete liver stores, and anyone whose absorption is significantly compromised (long-term metformin + PPI combination, post-bariatric surgery, atrophic gastritis on biopsy)

Important things to know: Temporary side effects (efectos secundarios): Common short-term reactions may include increased blood sugar levels, facial flushing, or mild insomnia following treatment

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When modeling continuous data, the benchmark response is the percent change in mean response relative to the respective controls, which is defined as critical effect size (RIVM 2021)