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MariTide (Amgen) is a once-monthly injectable that acts as a GIP antagonist combined with a GLP-1 agonist, showing roughly 12% to 16% weight loss in Phase 2 and now in Phase 3

The peptide exhibits anti-inflammatory properties by modulating cytokine production, reducing excessive inflammatory mediators like TNF- and IL-6 while supporting resolution of inflammation and transition to tissue repair phases

A 20 percent change from baseline is generally considered meaningful based on power analysis of the published data, but detecting this requires sufficient sample consistency

scopolamine aCSF group's learning curve (***p .001)