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5 ,N 10 -Methylen-5,6,7,8-tetrahydrofolsure herstellt durch Umsetzung bei Raumtemperatur der 5,6,7,8-Tetrahydrofolsure in Wasser mit einer Verbindung, ausgewhlt aus der Gruppe, bestehend aus Alkalihydroxiden, Alkalicarbonaten, Alkalihydrogencarbonaten, Ammoniak und organischen, Stickstoff enthaltenden Basen, wie beispielsweise Pyridin, Triethylamin, Triethanolamin, dann zu dieser so hergestellten Salzlsung eine wasserlsliche, aromatische, Stickstoff enthaltende Base hinzugibt, welche insbesondere ausgewhlt ist aus der Gruppe, bestehend aus Pyridin und substituierten Pyridinen, beispielsweise Picoline, Lutidine, Ethylpyridine, wobei Pyridin bevorzugt ist, dann diese so hergestellte Salzlsung mit Formaldehyd zur Reaktion bringt, und anschliessend eine wssrige Lsung eines Calciumsalzes hinzugibt, wobei das Calciumsalz der N 5 ,N 1 -Methylen-5,6,7,8-tetrahydrofolsure ausfllt.14

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Transcriptomic profiling of NPCs in ASD subtypes We identified 103 DEGs common to ASD-DM and ASD-N compared to TD-N, while 178 genes were uniquely dysregulated in ASD-DM vs TD-N (Figure 1I)

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