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Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth

Aggregates form when peptides interact through hydrophobic surfaces, -sheet formation, or disulfide bond scrambling

Despite being the basis of HCU management, conventional therapies have non-negligible limitations, including variability in patient responsiveness to B6