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Microglial cells show increased expression of LAG3, their activation leads to increased oxidative stress, resulting in neuroinflammation

Curr Clin Pharmacol 11(2):110117 Kim J, Basak JM, Holtzman DM (2009) The role of apolipoprotein E in Alzheimers disease

This diffuse phenomenon involves epithelial cell damage, lymphocyte penetration, and fibrotic changes, ultimately resulting in the progressive destruction of the thyroid gland