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Eventually, the main determinant of brain delivery efficacy is the concentration of the active (parent) drug at site of action in the brain or an increase of the relative distribution of parent drug between the brain and other tissues after administration of prodrug or nanocarriers compared to parent drug dosing

Amantea D, Marrone MC, Nistic R, Federici M, Bagetta G, Bernardi G, Mercuri NB

Describing drug disposition with compartment models creates differential equations that describe drug concentration changes in each compartment and provides a visual representation of the rate processes among compartments

Pair with good sleep, protein-centred meals and smart training for best results