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However, individuals with MTHFR polymorphisms or low baseline homocysteine metabolism may benefit from precautionary methyl donor support

It is considered an investigational compound and is typically sold by research chemical suppliers under the label for research purposes only

[6] [8] Estradiol cypionate is contraindicated during pregnancy because exogenous estrogen has no therapeutic role in gestation and in utero exposure could theoretically disturb fetal endocrine development or contribute to structural anomalies, although robust human teratogenicity data are limited

Medical professionals carefully monitor these effects to ensure patient safety throughout the treatment process