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Simsek-Duran F, Li F, Ford W, Swanson RJ, Jones HW, Castora FJ

While the drug initially showed promise in a Phase 2 study, a large Phase 3 trial failed to meet its primary endpoint, raising major doubts about efficacy.24 No trials of TUDCA alone have shown clear clinical benefit in ALS, and regulatory approvals for the combo have already been withdrawn in the U.S

Compared to WT, GPX2 KO PEN cells exhibited increased cytoplasmic stress, as measured by H 2 DCFDA, while no changes in mitochondrial stress levels were detected by MitoSOX staining (Fig

Tamaru M, Akita H, Fujiwara T, Kajimoto K, Harashima H (2010) Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis