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Thats the difference with the conventional model, which is often oriented more around symptoms suppression and disease management, irrespective of the underlying cause

(III) The design of a GSH-responsive and -exhausting drug delivery system can achieve tumor specific ablation to a certain extent

Thus, modulating the Fc:FcRn interaction to prolong plasma half-life and attain a favorable biodistribution is a clinical success, and several clinical-stage candidate therapeutics harbor either the YTE or LS amino acid substitutions, or a more recently reported triple Fc mutant variant (Q311R/M428E/N434W

Int J Radiat Oncol 84(3):S842, 2012