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By using fibroblast cell lines we overcome the limited accessibility of the affected tissues, which in the case of mitochondrial disorders are often high energy demanding tissues like brain, heart, skeletal muscle or liver

brigens untersttzen die antioxidativ wirkenden Vitamine B9 (Folsure), B12 und C sowie Spurenelemente Selen und Zink die Funktionalitt des Master-Antioxidans Glutathion optimal, da die antioxidativen Mechanismen wie in einem Orchester zusammenarbeiten

Additionally, we harvested and immortalized the stromal vascular fraction (SVF) from the inguinal WAT of Slc25a45 flox/flox , from which we established SLC25A45 KO cells and control cells by infecting immortalized SVFs with a retroviral Cre (pMSCV-Cre) or empty vector as control ( Fig