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Fluorescence staining indicated that both mitochondrial and intracellular ROS levels were significantly increased when HIF2 or MCJ was knocked down

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Oral administration of rhein (150 mg/kg in water) for 40 days significantly increased energy expenditure, reduced body weight, particularly body fat content, improved insulin resistance, and lowered circulating cholesterol levels in DIO mice

Modulating the expression of specific genes involved in collagen synthesis and tissue regeneration promotes firmer and healthier skin while supporting overall cellular health