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Globally, I believe [no current data to support this] that large doses of oral B12 have been used to some good effect, although it's not possible to work out who will benefit unless you do the experiment, and for that, if it meets the criteria of a clinical study, it needs [certainly in the UK] to be appropriately designed and reviewed before the work starts, and the results should be presented afterwards

College Pharmacy and Wellness Pharmacy both ship hydroxyB-12 on ice

Indeed, we expect that not all targets will have geometries that will accommodate or otherwise be suitable for high-affinity binding to a helical segment

Scheithauer TPM, Rampanelli E, Nieuwdorp M, Vallance BA, Verchere CB, van Raalte DH, Herrema H