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If the softer feel you notice is really about loaded voltage drop, the next useful read is What Is Voltage Sag

Melanocortin Receptor Subtype Activity MT-2 engages melanocortin receptors across four subtypes with varying affinity: MC1R (melanocytes eumelanin synthesis), MC3R (hypothalamus and peripheral tissues energy homeostasis), MC4R (hypothalamus and limbic system appetite, arousal, autonomic function), and MC5R (exocrine glands secretory functions)

PT-141, also known as Bremelanotide, acts as a melanocortin receptor agonist that stimulates melanocortin receptors in the brain associated with sexual desire and arousal