Namely, we fed C57BL6/J mice a chow (Chow) or high-fat, fructose, cholesterol (FFC) diet and co-administered either saline or EtOH

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Protects against mitochondrial DNA degradation and assists in sustaining sufficient energy (ATP) output to match cellular energy demands
To examine the effect of FBXL5 depletion on the NF-B signaling pathway, we compared the time-course changes in the phosphorylation status and abundance of IKK and IB upon LPS stimulation in WT and FBXL5 KO DC2.4 cells