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Based on another RCT, a single dose of B12 (500 g/d) or its combination with B1(300 mg/d), B6 (80 mg/d), and B9 (2mg/d) during 12 weeks had favorable effects on the frequency of headache attacks and migraine disability (73)

Of the supplements and pharmaceuticals studied, oral glutathione, rasagiline, and coenzyme Q10 were associated with improved PRO-PD scores, whereas iron was associated with more severe disease