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This gradual escalation prevents overwhelming side effects like flushing, nausea, or headaches that occur when starting at high doses, allows the pituitary to adapt to regular stimulation improving long-term response, and provides opportunity to identify minimal effective dose avoiding unnecessary higher dosing and associated costs

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doi: 10.1126/science.273.5277.974 28 HuaT.VemuriK.NikasS

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Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications

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