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Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice

Metabolic parameters including glucose tolerance, insulin sensitivity, and IGF-1 levels were monitored throughout the treatment period, confirming that the favorable metabolic profile persisted with chronic use

Because it acts at the cellular level rather than on appetite or hormones, interest in it extends beyond weight loss into longevity and metabolic disease prevention

Additionally, B12 deficiency can cause mood disorders like depression, which may contribute to emotional eating or a lack of motivation to maintain a healthy lifestyle, further impacting weight