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Meeker JD, Susi P, Flynn MR

Similarly, hearts from transgenic mice overexpressing GPx1 had preserved mitochondrial and cardiac function in the presence of doxorubicin, with increased efficiency of mitochondrial respiration and better contractility and diastolic function compared wild type hearts exposed to doxorubicin [44]

However, the realization of this potential will require a sustained commitment to rigorous, mechanism-guided, and translation-oriented research paradigms