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Description

Biotechnol Lett 26:415417

In addition, Nrf2 induces the expression of SLC7A11, which promotes cystine uptake and supports GSH production, thereby reinforcing the cellular defense against ferroptosis ( Nrf2 also plays a role in iron metabolism, which is closely linked to ferroptotic susceptibility

(1 shake) per 30 pounds of body weight

Subsequent assessments of mitochondrial function demonstrated that PX-478 treatment severely impaired mitochondrial activity, as evidenced by decreased ATP-linked OCR, reduced MMP, and lower ATP levels (Fig