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High SAH levels particularly affect DNA methyltransferases, impacting the methylation status of certain genes, including the hTERT gene, which has implications for kidney function [60]

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The baseline clinical characteristics of the different groups are shown in Table 2

In contrast, under oxidative stress conditions, Cys273 and Cys288 cysteines on Keap1 protein are rapidly oxidized, leading to the loss of Keap1 protein-mediated ubiquitination modifications and the translocation of Nrf2 to the nucleus, where it binds to multiple AREs on DNA and initiates the transcriptional expression of multiple antioxidant proteins [131]