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Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6

Recent studies have highlighted the significant role of glial cells, including microglia and astrocytes, in the progression of PD (Wang et al., 2023

Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401- MITSUBA)

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