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Fractionation can be useful in two cases: to improve digestive tolerance (small intakes) or to integrate collagen into two rituals (morning + evening) when it simplifies things

In these subjects, neutrophils are in a more activated state with decreased antioxidant enzyme activities and increased susceptibility to activate the oxidative burst

For instance, increased levels of IL-6 can upregulate MCP-1 expression in endothelial cells and macrophages, establishing a positive feedback loop that amplifies the inflammatory response (137)