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It was built in the mid-15th century and it is believed that it was one of the residences of the ninth Inca of Tahuantinsuyo, Pachactec (Considered the great transformer of the Inca empire), although it also contains the remains of a great Sanctuary (Sacred Place where worshiped its various gods, especially the Sun God), with various temples such as: Temple of the Sun, Temple of the 3 Windows, Temple of Pachamama, Inti Huatana, the Royal Mausoleum, among others, Its name means old mountain Machu Picchu, and refers to the place where it is located, at about 2,453 meters above sea level, on a rocky premonitory between Machu Picchu and Huayna Picchu

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In senescent cells, FOXO4 binds to the tumor suppressor protein p53 and prevents it from initiating apoptosis