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The Nrf2 Transcription Factor Protects from Toxin-Induced Liver Injury and Fibrosis

Interestingly, some cells opt for pyruvate reduction even with oxygen, a process known as the Warburg effect, which maintains energy equilibrium

By inhibiting the inflow of Ca 2+ , mitochondrial ROS production and the accumulation of polyunsaturated fatty acids (PUFA) are reduced, and the ferroptosis finally inhibited (Zhang et al., 2024) Eventually, mitochondria mediate ferroptosis through double regulatory factors

Succinate-ubiquinone reductase linked recycling of alpha-tocopherol in reconstituted systems and mitochondria: requirement for reduced ubiquinone