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Step 2 The product of step 1 (41.0 g) and KOH (32.0 g) was dissolved in 200 ml of methanol, added 35.5 ml bromoethane, heated under reflux for 2 h, added 200 ml of 5% NaOH after cooled, and reacted for 34 h, added 600 ml ice water after reaction, stirred, rested and filtered, washed with water, recrystallised with 500 ml ethanol and dried at 80 C

ROMANA 3: a phase 3 safety extension study of anamorelin in advanced non-small cell lung cancer (NSCLC) patients with cachexia

Cell 80 , 592606.e598 (2020)

In the male offspring, increased fission markers and reduced autophagosome markers at P1 suggesting an increase in mitochondrial damage and thereby overconsumption of the autophagosome, while data from adult offspring suggest reduced mitophagy but increased cellular damage