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The pharmacokinetics of bupropion, which is extensively metabolized by the CYP450 (CYP2B6), was not affected by moderate (~ 0.30.4 g/L) nor by high (~0.8 g/L) BACs (276)

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Other Risks Fluoxetine has been associated with other health complications, such as: Difficulty concentrating and impaired judgment, thinking, and motor skills Anxiety and insomnia Changes in appetite and significant weight loss Bleeding problems, including gastrointestinal bleeding Serious medical problems such as angle-closure glaucoma Hyponatremia (low sodium levels) QT prolongation and ventricular arrhythmia Changes in sexual ability Priapism (painful or prolonged erection) Only 1% of maternal use of SSRIs has been linked to persistent pulmonary hypertension of the newborn, a fatal condition associated with the use of antidepressants during the second half of pregnancy