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To explore whether changes in the RG or BP population were underlying the reduced neurogenesis in Gpr124 KO as compared to WT embryos, we stained for the cortical RG marker Pax6 and the BP marker Tbr2

Research Applications Obesity and body weight regulation research Type 2 diabetes and glycemic control studies Appetite and satiety pathway research Amylin and GLP-1 receptor signaling studies Gastric emptying and postprandial glucose research Combination peptide pharmacology studies Energy intake and food reward research Cardiometabolic risk factor studies Hypothalamic appetite circuit research Comparative metabolic peptide studies Safety Profile The safety profile of the cagrilintide + semaglutide blend draws on the substantial individual safety datasets for each peptide as well as growing combination data from Phase 1b and Phase 2 clinical research

Risk Mitigation Measures and Study Monitoring The study monitoring and risk mitigation strategy should be predetermined and supported by a well-defined rationale

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