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Potential drug candidates therefore should target these toxic oligomers, by either inhibiting their formation or otherwise decrease their concentration

Dervan A, Franchi A, Almeida-Gonzalez FR, Dowling JK, Kwakyi OB, McCoy CE, et al

These losses lead to impaired axonal function, increased vulnerability of axons to damage, and result in significant brain atrophy and neuro-axonal degeneration