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Other differences between these studies were the choice of ovarian insult, with our study using doxorubicin and cisplatin, rather than cyclophosphamide and -irradiation, and the choice of timepoint, with our studies conducted at 2 months post-chemotherapy, rather than 5 days

Choline is needed for optimal production of acetylcholine , which is the main neurotransmitter involved in memory and learning

A number of possible mechanisms have been discussed in the literature

However, here are some general guidelines: For individuals with a B12 deficiency, a common protocol may involve a daily dosage of 1,000 mcg for one week, followed by the same dosage once weekly, and then once per month after addressing the deficiency