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Description

The second and third most abundant IGFBPs are IGFBP-2 (32 kDa) and IGBP-1 (28 kDa), which can also bind IGF-1 and IGF-2, and are thought to modulate IGF actions by competing with the IGF receptors

PMID 28780990

Thats where problems begin, often quietly, until symptoms start stacking up

Their activities reflect the dynamic nature of muscle filament assembly, as they are involved in actin filament polymerisation (GO:0030041) and depolymerisation (GO:0030042), and both the regulation (GO:0030834) and negative regulation (GO:0030835) of depolymerisation