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This makes the monotherapy regression coefficient less robust than the combination finding Heterogeneity in protocols: The included studies used different needle depths (0.52.5 mm), frequencies (weekly to monthly), devices (dermaroller, dermapen, fractional radiofrequency), and treatment durations, which adds variability to the pooled analysis Primarily male populations: Most included studies focused on male androgenetic alopecia

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Small clinic case series (knee pain): One frequently cited study involved 12 patients with knee osteoarthritis or injury who received BPC-157 injections into the knee joint

Subcutaneous injection provides systemic distribution, but topical application targets specific areas of concern