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The intense inflammatory reaction to this airway infection consists of chemokine and cytokine expression (IL-8 and tumor necrosis factor (TNF)) and mucin secretion 12 , as well as PMN accumulation 13 and the associated release of serine proteases 14, 15 , which are themselves proinflammatory stimulants 16, 17

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Short-term priorities: biomarkers of organelle-level zinc dyshomeostasis A major limitation in current clinical practice is that circulating zinc concentrations provide little insight into intracellular zinc distribution or the functional state of zinc-dependent organelles

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