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In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Chao AM, Tronieri JS, Amaro A, et al

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