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Detoxification, methylation and anti-oxidants continue to play an important role in the biomedical treatment of autism and other chronic medical conditions

Thus, the PPPgenerated NADPH rescues xCT-overexpressing cancer cells (xCT high cancer cells) from ferroptosis, demonstrating that xCT high cancer cells become highly dependent on the glucose-PPP pathway (i.e., NADPH addiction) to inhibit ferroptosis [Figure 1A]

Gln metabolism directly or indirectly influences epigenetic processes, such as DNA methylation and histone modification, through mechanisms of substrate supply and cofactor regulation