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Future outlook: data from preclinical studies Although the mechanisms underlying CIPN are relatively well understood, the available results of clinical trials clearly indicate that the success rate for the introduction of novel drugs that are able to prevent CIPN is low [50], the progress in this area is slow and, at present, there is insufficient evidence to recommend any specific agent for CIPN prevention

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Erb, Holger HH, et al

Anything which irritates the mucosal lining of the nose wouldnt be tolerated, congested nasal passages could inhibit delivery, and its not clear how far or where into the brain the substances might reach