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doi: 10.1038/s41467-018-05470-4 162 RoderburgC.LueddeT

In addition, pharmacological intervention with SAHA also restored the histone H3 acetylation level, reversed pathological form of synaptic plasticity, and abrogated the epileptic phenotype in the TSC2 +/ mice showing the neurological manifestations including seizures, autism and cognitive deficits [138]